1 During this same period, acetanilide and phenacetin were derived from para-aminophenol compounds in coal tar, and pyrazolon compounds such as aminopyrine were developed. In 1899, the Bayer Company launched the modern era of antipyretic therapy with the introduction of aspirin as the world's first commercially available antipyretic drug.
Salicylic acid was first synthesized by Gerland 5 in 1852, some 8 years before Kolbe and Lautemann, 6 who are frequently credited with this accomplishment, and just a year before von Gerhardt 7 developed acetylsalicylic acid (aspirin) during efforts to find a more palatable form of salicylate. 3 Less than 80 years later, Piria 4 succeeded in preparing salicylic acid from salicin, a glycoside component of willow bark. 2 However, it was not until 1763 that the Reverend Edward Stone gave the first scientific description of the clinical benefits of willow bark to the Royal Society of London.
1, 2 Ancient Assyrian, Egyptian, and Greek physicians all apparently knew of and exploited the antipyretic property of extracts of the bark of the willow ( Salix alba).
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